Takotsubo cardiomyopathy has already cardiac biomarkers, such as the NT-proBNP (N-terminal B-type natriuretic peptide)/myoglobin and NT-proBNP/troponin T ratios for the diagnosis of acute coronary syndromes and stress-induced cardiomyopathy (61). Here, NPPB is linked to Tako-tsubo cardiomyopathy.