In the context of NDs, yeast have been particularly useful in understanding protein misfolding and subsequent cellular toxicity in HD (huntingtin), PD (α-synuclein), and AD (tau, Aβ), as well as fundamental cellular processes because of the strong conservation of gene function between humans and yeast (Winderickx et al., 2008; Liu et al., 2017; Delenclos et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.