Ineffective insulin function, either due to a lack of insulin or/and insulin resistance, leads to failure during the activation of this enzyme, resulting in hypertriglyceridemia.55,56 The significant control of serum triglyceride levels in diabetic rats treated with SynacinnTM might be attributed to an enhancement in insulin levels or the insulin-like activity of this polyherbal formulation. The gene discussed is INS; the disease is Insulin resistance.