TNNT2 and atrial fibrillation: AF was identified in 10% of patients with sporadic TNNT2 mutations (D86A, R94H, K97N, ΔE160, ΔE163, L178F, N262S, N269K, and ΔW287), while AF occurrence was much higher (25–75%) in patients carrying specific “hot-spot” mutations (I79N, R92Q/W, F110L, R130C, R278C, and R286C).