For example, the AQP5 C-terminus was found to interact with prolactin-inducible protein (PIP) in control mice (Jcl:ICR, CLEA Japan), but interact with major urinary protein 4 in non-obese diabetic (NOD) mice (model for Sjögren’s syndrome) (Ohashi et al., 2008). Here, AQP5 is linked to Sjogren syndrome.