Interesting, the results of this study used AVE-0657 to treat Ang II-infused, high salt-fed-indued hypertensive mice are similar to or consistent with PT-Nhe3−/− mice with or without Ang II-infused, high salt-fed-indued hypertension (Li et al., 2018, 2019b). Here, SLC9A3 is linked to hypertensive disorder.