In addition to well-recognized AT1 receptor-mediated effects on NHE3 expression and activity, a defect in AT2 receptor-mediated inhibition of NHE3 expression and activity has been reported in the proximal tubules of SHRs, which may contribute to the development of hypertension in SHRs (Kemp et al., 2014, 2016, 2022; Zhuo and Li, 2019). This evidence concerns the gene SLC9A3 and Hypertension.