Nevertheless, the roles of these alternative pathways in the regulation of NHE3 expression and activity and subsequent Na+ reabsorption from the proximal tubules, blood pressure control, and the development of Ang II-dependent hypertension may be much smaller than those of the predominant Ang II/AT1 (AT1a)/NHE3 signaling pathways. Here, AGTR1 is linked to hypertensive disorder.