The Na+/H+ exchanger 3 in the proximal tubules of the kidney has long been implicated in the development of hypertension in spontaneously hypertension in rats (SHRs; Thomas et al., 1988, 1990; Kelly et al., 1997; Aldred et al., 2000; LaPointe et al., 2002; Kemp et al., 2014, 2016, 2022). This evidence concerns the gene SLC9A3 and hypertensive disorder.