IL6 and brain inflammatory disease: For example, triggering receptor expressed on myeloid cells 1 (TREM1), which is related to microglial maladaptive responses, shows a significant increase following the induced brain inflammation cause by LPS [50, 51], and also LPS can be a stimulus for microglial activation, causing the elevated expression of the toll-like receptors (TLR) [52, 53], the enhanced secretion of the neural damage correlated proinflammatory molecule interleukin 6 (IL-6) [54, 55].