SOX4 and urinary bladder carcinoma: Several researches verified that Sox4 is a critical oncogene that is highly expressed in cancers, including prostate cancer [49], colorectal cancer [50], bladder cancer [51], and breast cancer [52], etc. Sox4 has also been testified to be associated with differentiation, metastasis, and chemoradioresistance in OSCC [53, 54].