Additional file 1: Fig. 1 shows TDP-43-positive neuronal cytoplasmic inclusions (arrows) in dentate gyrus granule cells in a case with frontal lobe dementia (FTLD, established positive internal laboratory control) and in a case with Alzheimer disease (case 15, Braak VI, CERAD C) positive for hippocampal TDP-43 pathology. Here, TARDBP is linked to early-onset autosomal dominant Alzheimer disease.