In the present work, we investigated the expression of IGFBP5 in the hippocampus of Alzheimer’s disease postmortem brain and tested in mice the effects of elevated Igfbp5 expression on hippocampal Bdnf protein levels and whether Igfbp5 might impair with the effects of exercise on cognition. This evidence concerns the gene IGFBP5 and Alzheimer disease.