Additional file 1: Fig. 1 further shows immunostaining from another Alzheimer's disease case (case 13, Braak V, CERAD C) that did not have neuronal TDP-43-positive cytoplasmic inclusions in dentate gyrus granule cells (negative for hippocampal TDP-43 pathology). The gene discussed is TARDBP; the disease is early-onset autosomal dominant Alzheimer disease.