Weak IGFBP5-IR was also detected in vascular walls of cortical blood vessels in control cases 1 and 2 and in AD cases 11 and 16, whereas no IGFBP5-IR was detected in hippocampal blood vessels in all cases listed in Table 1 (Additional file 1: Fig. 5). The gene discussed is IGFBP5; the disease is Alzheimer disease.