Pathway analysis of the putative PDGF-BB-regulated genes showed that these had highly pleiotropic effects of potential relevance for allergies: B cell signaling, cell migration and proliferation, immune response, and cytokine-related pathways, for example, via IL-6, IL-7, IL-8, and IL-15 signaling (Additional file 9). This evidence concerns the gene CXCL8 and Allergy.