Although lncRNA could interact with miR-15a-5p in diseases, such as the regulatory mechanism of lncRNA CERS6 antisense RNA 1 and miR-15a-5p in pancreatic cancer [22], the relationship between AFAP1-AS1 and miR-15a-5p in EMS is rarely reported in existing works. Here, AFAP1 is linked to familial pancreatic carcinoma.