In the first trimester, the levels of TC, TG, HbA1c and CRP of pregnant women in the macrosomia group were higher than those in the non-macrosomia group (P <  0.05), whereas, there was no significant difference on the levels of SBP, DBP, ALT, AST, ALB, HDL, LDL, FPG, SCr, UA, FT4, FT3 and TSH between the two groups (P > 0.05) (Table 1). The gene discussed is GPT; the disease is Large for gestational age.