The total group of pathologists showed a slight agreement on AChE + HE (Fleiss’ kappa: 0.20), a substantial interobserver agreement on calretinin (Fleiss’ kappa: 0.76), and a substantial agreement on AChE + HE and calretinin (Fleiss’ kappa: 0.64). The gene discussed is ACHE; the disease is hereditary elliptocytosis.