The data obtained from these tumours are also consistent with an upregulation of anti-angiogenic ING4 mRNA levels in the human xenograft tumours in vivo (Fig. 6d), with no significant changes are detected for ANG, VEGFA, HIF1α, THBS2 and COL18A1 (Fig. 6c, d). Here, COL18A1 is linked to neoplasm.