Furthermore, cryo-EM analysis of TDP-43 filaments formed from SegA (residues 311–360) and SegB (residues 286–331 including the ALS hereditary mutation A315E) peptides has revealed three different dagger-shaped core structures from SegA filaments and one core structure composed of four R-shaped folds from SegB filaments [56]. Here, TARDBP is linked to amyotrophic lateral sclerosis.