Prion protein (PrP), which causes prion diseases such as Creutzfeldt–Jakob disease and bovine spongiform encephalopathy, is rich in α-helices in the normal state (PrPC), whereas when converted to the abnormal form (PrPSc), it forms amyloids rich in β-sheet structures[171, 196, 222]. Here, PRNP is linked to prion disease.