In AGD, FTDP-17T (intron 10 mutations + 3 and + 16) and aging-related tau astrogliopathy (ARTAG) cases, a fibrous core structure akin to the CBD fold, consisting of G273-D387 or N279-N381 in 4R tau, was identified (Table 1) [266]. This evidence concerns the gene MAPT and argyrophilic grain disease.