βOHB stimulation reduced the expression of atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), transforming grow factor-β (TGF-β) and connective tissue growth factor (CTGF), suggesting the protective role of βOHB and FGF21 against cardiac hypertrophy. This evidence concerns the gene NPPB and cardiac hypertrophy.