Shank proteins are synaptic cytoskeleton-associated proteins that interact with SAPAPs, and previous studies identified a role for Shank3 in epilepsy [15–17] and indicate that PSD95/SAPAP/Shank multiprotein units might play an important role in organizing the postsynaptic signaling complex at glutamatergic synapses [18, 19]. The gene discussed is SHANK2; the disease is epilepsy.