TIGIT and infection: Finally, we validated in vivo that Als6, Als7, and Als9-2 are indeed TIGIT ligands by infecting mice intravenously with als6Δ/Δ, als7Δ/Δ, or als9Δ/Δ mutants or the WT strain of C. albicans and measuring both mouse survival over time and fungal burden within the kidneys 48 h post-infection.