In addition, a signature of eEF2K activity (as measured by its autophosphorylation and phosphorylation of its substrate eEF2) was found to be associated with sensitivity to cotreatment in cell models of acute myeloid leukemia (AML) and could thus represent a biomarker signature to predict synergistic response to cotreatments with MEK and PI3K inhibitors. Here, MAP2K7 is linked to acute myeloid leukemia.