da Costa et al,[7] investigated the serum levels of LTBP2 in a prospective cohort of 115 patients with chronic liver disease from Korea between 1999 and 2001, and found that increased serum LTBP2 was detected in 21 subjects who developed HCC, which improved biomarker-based detection of HBV-related HCC. Here, LTBP2 is linked to hepatocellular carcinoma.