LTBP2 and head and neck squamous cell carcinoma: For example, Han et al,[5] found that LTBP2 protein expression was significantly higher in head and neck squamous cell carcinoma tissues, and was associated with lymph node metastasis and higher tumor node metastasis (TNM) stages, suggesting that LTBP2 served as an independent prognostic biomarker in head and neck squamous cell carcinoma (HNSCC).