Interestingly, the combination of CALR and disulfide isomerase (PDIA3) was found to be a potential prognostic biomarker for non-small-cell lung cancer [197], which coincides with our finding of the upregulation of PDIA4 in ADC and PDIA3 and PDIA4 in SCC tissues. Here, PDIA4 is linked to AIDS dementia complex.