CASP8AP2 and acute lymphoblastic leukemia: However, in bone marrow and in minimal residual disease (MRD) samples, the combined detection of low miR-210 expression and of low expression of caspase 8-associated protein 2 (CASP8AP2), a pro-apoptotic protein suggested a promising prognostic indicator for hematological relapse, was associated with a poor outcome in pediatric acute lymphoblastic leukemia [68].