CASP3 and Familial prostate cancer: Reported to be downregulated in human castration-resistant prostate cancer tissues, the forced miR-328 overexpression in mimic miR-328 transfected-prostate cancer cell line resulted in the enhancement of cell sensitivity to the chemotherapeutic drug docetaxel and in the induction of apoptosis associated with the increase of the cleavage of caspase-3 and caspase-9 (mitochondrial-dependent apoptotic pathway) [42].