Anemia in patients with heart failure, as well as hypoalbuminemia, is not only a reflection of nutritional status, but also a result of chronic inflammation caused by heart failure itself, concomitant renal dysfunction, reduced erythropoietin production and sensitivity, and suppression of hematopoietic stem cell function by ACE-Is and ARB. The gene discussed is EPO; the disease is Hypoalbuminemia.