In adjusted models, patients who reported 22–90 injections per month had no significant differences in sCD14 (AMD -126.4 [95%CI: -353.5, 100.6]), IL-6 (ARM 0.95 [95%CI: 0.66, 1.37]) and D-dimer (ARM 0.99 [95%CI: 0.69, 1.45]) levels compared to those who reported 1–3 injections per month. The gene discussed is IL6; the disease is age-related macular degeneration.