For instance, we detected altered binding of FOSL2 to mutant oligonucleotides harbouring the following five SNPs: rs8023164 (MS and SLE), rs17103360 (MS and RA), rs10515944 (CD), rs3116497 (CD) and rs7414934 (AS, CR, PS, RA, and UC) (Figure 8C; Supplementary Figure S9A, S10A). This evidence concerns the gene FOSL2 and systemic lupus erythematosus.