As commonly observed in lung cancer, loss of tumor suppressor genes TP53 and MAP2K4 and gain of TERT were identified in all samples; PTEN and APC losses were detected in GR-CDXL1 and GR-CDXL4 tumor samples and in GR-CDXL3 CDX and its cell line. The gene discussed is MAP2K4; the disease is neoplasm.