EDN1 and central nervous system cancer: RGMB, EDN1, SEMA3C and NRTN have been indicated to regulate olfactory neurogenesis, mesenchymal stem cells regeneration, tumorigenicity of glioma stem cells and neurite outgrowth, respectively (Hwang et al., 2021; Kam et al., 2016; Man et al., 2014; Reyes-Corona et al., 2017).