Further endocrine consequences of renal insufficiency entail normochromic, normocytic anemia due to erythropoietin deficiency as well as a change in bone metabolism (renal osteopathy) due to hyperphosphatemia and hypocalcemia in the absence of calcitriol, leading to secondary hyperparathyroidism with increased parathyroid hormone levels. This evidence concerns the gene PTH and anemia (phenotype).