In this context, in their 2014 study, Henriques et al. were able to show that a change in bone metabolism due to chronic renal insufficiency can be detected in dental X-ray diagnostics in male patients with severe secondary hyperparathyroism (PTH levels of ≥ 500 pg/ml) and a dialysis period of at least three years [10]. The gene discussed is PTH; the disease is chronic kidney disease.