Further endocrine consequences of renal insufficiency entail normochromic, normocytic anemia due to erythropoietin deficiency as well as a change in bone metabolism (renal osteopathy) due to hyperphosphatemia and hypocalcemia in the absence of calcitriol, leading to secondary hyperparathyroidism with increased parathyroid hormone levels. The gene discussed is PTH; the disease is anemia.