Recently, macrophage-expressing C-X-C motif chemokine receptor 3 (CXCR3) ligands including CXCL9 were found to recruit CD8-positive T cells and be indispensable for anti-tumour efficacy of ICIs [29, 30], suggesting the importance of cytocidal macrophages working against both tumour cells and beta cells. This evidence concerns the gene CXCR3 and neoplasm.