Secondly, a UALCAN analysis further revealed a possible link between DNMT1 and increased methylation in normal liver tissue relative to HCC tissue (p = 0.101, Figure 7B), while DiseaseMeth v 2.0 analysis showed that MELK methylation was significantly reduced in HCC tumors compared with paired normal tissues (p < 0.001; Figure 7C). Here, DNMT1 is linked to hepatocellular carcinoma.