A diverse set of stimuli and cellular processes induce non-canonical autophagy, including stimulation of the TRPML1 calcium channel (Goodwin et al., 2021), activation of the stimulator of interferon genes (STING) pathway (Fischer et al., 2020), and disruption of endolysosomal ion balance by pharmacological agents, such as Helicobacter pylori VacA toxin, or infection with influenza A virus (Fletcher et al., 2018; Florey et al., 2015; Jacquin et al., 2017). Here, STING1 is linked to infection.