TUBA1A and tubulinopathy: Based off our work and that of others, there does not appear to be a consistent mechanism for how TUBA1A tubulinopathy mutations affect microtubule networks and neuron cell biology (Aiken et al., 2019; Belvindrah et al., 2017; Gartz Hanson et al., 2016; Keays et al., 2007).