HSD17B2 and prostate neoplasm: Since the transcription of AS-HSD17β2 occurs from the antisense strand of the HSD17β2 locus at multiple transcription start sites (Figures 4 and 5), it is possible that decreased AS-HSD17β2 expression due to either reduced promoter activity or a different transcription start site leads to overexpression of HSD17β2 in prostate tumors.