RT-qPCR was then adopted to determine the expression patterns of SCARA5 in PC tissues, adjacent normal tissues, and pancreatitis tissues, which revealed that SCARA5 expression was remarkably down-regulated in PC and pancreatitis tissues relative to adjacent normal tissues; as compared to pancreatitis tissues, SCARA5 expression was markedly decreased in PC tissues (Figure 2e). The gene discussed is SCARA5; the disease is pachyonychia congenita.