Additionally, SCARA5 is also known to be capable of suppressing tumor proliferation and invasion by inhibiting the FAK pathway.29,43 The FAK pathway is responsible for the cell migration and angiogenesis, while repression of the FAK pathway can inhibit cell motility and proliferation.44,45 Moreover, a plethora of studies have previously indicated inhibition of FAK as a therapeutic strategy against PC,46–48 which also roused us to explore whether miR-331-3p in CAFs-derived EVs promotes the development of PC by regulating the SCARA5/FAK axis. Here, PTK2 is linked to pachyonychia congenita.