Therefore, we summarize the whole process of FOXO4‐DRI works on BLM‐induced PF as follows, FOXO4‐DRI eliminated senescent cells, downregulation of SASP released by senescent cells reduce the inflammatory stimulation to neighbour cells to rescue BLM‐induced PF; On the other hand, FOXO4‐DRI is more inclined to kill myofibroblasts, downregulated the expression of main ECM proteins, reduced ECM formation and finally inhibited ECM‐receptor interaction to mitigate BLM‐induced PF. The gene discussed is FOXO4; the disease is pemphigus foliaceus.