Notably, PFD could not increase the cell number of AEC2 in our experiment, also, FOXO4‐DRI could not improve the percentage of endothelial cells, which can be rescued by PFD; Above data suggested that FOXO4‐DRI may rescue BLM‐induced PF through eliminate myofibroblasts and promote recovery of fibroblast and AEC2 number. The gene discussed is FOXO4; the disease is polyostotic fibrous dysplasia.