Moreover, defining thoroughly the nature of tumor cell death in ascites induced by the combination of IL‐6, TNF‐α, and IFN‐γ, which had previously been reported to induce immunologically lymphocyte proliferation, and dissecting the signaling pathways are critical to understand the interplay between mechanisms of cell death and how they may affect the tumor microenvironment. The gene discussed is IL6; the disease is neoplasm.