For malignant ascites caused by gastrointestinal tumors, systemic or local infusion of chemotherapy alone is a common upfront line treatment which could also combine with other antiangiogenic agents, including vascular endothelial growth factor (VEGF) antagonists and immune checkpoint inhibitors for selected patients, confirmed by abundant preclinical and clinical evidences.6, 7, 8, 9. This evidence concerns the gene VEGFA and digestive system neoplasm.