GDF15 and metabolic dysfunction-associated steatotic liver disease: Plausible mechanisms based on known stimuli of GDF15 expression (Hsiao et al., 2000) in the liver include Vpr‐induced mitochondrial dysfunction (Agarwal et al., 2021) and overall hepatocellular stress induced by multiple mechanisms leading to NAFLD (Agarwal et al., 2017) in the Vpr mice.