The FLG gene has been found to be significantly mutated or amplified in some types of cancer, such as colorectal carcinomas (40), differentiated thyroid cancer (41), gastric cancer (42), breast cancer (43), colorectal cancer (44), penile squamous cell carcinoma (45), glioblastoma (46), nasopharyngeal carcinoma (47), malignant melanoma (48), hepatocellular carcinoma (49), and uterine leiomyosarcoma (50). The gene discussed is FLG; the disease is melanoma.