Children with troublesome asthma (n = 6) had higher IgE levels to dog dander (57 vs. 11 kUA/L, p = 0.017) and to the dog lipocalins Can f 2 (44 vs. 4.1 kUA/L, p = 0.015), Can f 4 (5.8 vs. 0.9 kUA/L, p = 0.018) and Can f 6 (1.3 vs. 0.7 kUA/L, p = 0.03) compared to the rest of the study population (n = 53), see Figure 3. This evidence concerns the gene IGHE and asthma.