As reported previously, the adipocytokine signaling pathway is closely related to lipid metabolism and obesity, so MAPK8, RXRA, RXRB, and AKT2, which are involved in the adipocytokine signaling pathway and were screened as intersecting targets in network pharmacology/transcriptomic/obesity-related genes, were considered candidate genes for molecular docking and verification. This evidence concerns the gene MAPK8 and obesity disorder.