In patients with MDD showing response to paroxetine treatment, putative hydroxypyruvate isomerase (HYI), eukaryotic translation initiation factor 4H (eIF4H), and RNA binding motif 8A (RBM8A) were differentially expressed before and after treatment, as identified by iTRAQ and validated by Western blot. This evidence concerns the gene RBM8A and major depressive disorder.