In animal model of depression, iTRAQ analysis identified 241 differentially expressed proteins in hippocampi after Chinese herbal medicine xiaochaihutang (XCHT) treatment, and protein-protein interaction network analysis predicted cell division cycle and apoptosis regulator protein 1 (Ccar1) and Calretinin (Calb2) might play the central roles in XCHT's antidepressant network (65). Here, CCAR1 is linked to major depressive disorder.