Mutation of OPA1 gene has long been associated with dominant optic atrophy (58), but neurodegenerative symptoms had also been reported, as such parkinsonism and dementia (59), multiple sclerosis-like disorder (60), and fatal infantile mitochondrial encephalomyopathy (61). This evidence concerns the gene OPA1 and adult-onset autosomal dominant demyelinating leukodystrophy.