In this study, PATZ1 can be involved in regulating the expression of apoptosis-related factors, such as promoting the expression of apoptosis-related classical genes PARP1, caspase 3, caspase 9, and Bax and inhibiting the expression of Bcl-2, directly or indirectly inducing apoptosis in GBM tumor cells. The gene discussed is PARP1; the disease is glioblastoma.