FLT3 and acute myeloid leukemia: For example, midostaurin is Food and Drug Administration- (FDA-) approved for use in combination with chemotherapy for newly-diagnosed Fms-like tyrosine kinase 3- (FLT3-) mutated AML, and gilteritinib is FDA-approved as a single agent salvage therapy for patients with relapsed or refractory FLT3-mutated AML.