A pathologically higher PRL level in patients with T2DM in a few studies has also been shown to be associated with increased diabetic complications, insulin resistance, and metabolic syndrome [17]. The Framingham Heart Study observed an incremental rise in incident T2DM in the male population with every 5 mg/dl increase in serum PRL levels (OR: 1.70, 95% CI: 1.04-2.78, P = 0.03) [5]. This evidence concerns the gene PRL and type 2 diabetes mellitus.