There was no significant correlation between the expression of Smurf2 and gender, age, hepatitis B surface antigen (HBsAg), α-fetoprotein (AFP), liver cirrhosis, tumor number, tumor size, tumor encapsulation, tumor differentiation or tumor-nodes-metastasis (TNM) stage, and Barcelona Clinic Liver Cancer (BCLC) stage. This evidence concerns the gene SMURF2 and cirrhosis of liver.