CYTL1 and type 1 diabetes mellitus: In prior work, we have shown high expression of Cytl1 in the mid layer of the articular cartilage and that this expression was reduced as a result of injury and aging.(24, 33) Consistent with lower cartilage degradation in the injured T1MD mice, this group also showed significantly higher levels of type II collagen (Col2) protein expression when compared with injured control and with uninjured T1D controls (Fig. 4A).