Although we identified a significant reduction in Col2a1, Sox9, and Acan expression in both T1DM and C57BL/6J control injured groups, the T1DM injured joints displayed a significant increase in the number of Col2a1‐, Sox9‐, and Acan 1‐expressing chondrocytes when compared with the injured control joints at 7 days post‐injury. This evidence concerns the gene COL2A1 and type 1 diabetes mellitus.