MEN1 and osteoporosis: Consequently, menin may be a potential gain‐of‐function therapeutic target for the treatment of the osteoporosis observed in PHPT with MEN1, whether by genetically restoring levels of menin in bone, reversing epigenetic changes caused by loss of menin function, for example, by inhibition of histone demethylases(56) or restoring downstream changes in menin signaling.(57) Whether strategies aimed at enhancing menin activity in bone may also be therapeutically useful in other forms of osteoporosis remains to be determined.