BCL2 and cancer: The most significant finding of our research is that oral administration of paclitaxel-containing extract exerts anti-cancer effect in A549-bearing nude mice, and HDS-1-derived flavonoids and lignoids contribute to their anti-cancer effect through enhancing enterocyte absorption of paclitaxel and augmenting cytotoxicity and BCL-2-related cell death of paclitaxel (Figure 10).