We were interested in investigating alterations in these immune compartments in SLE patients with a recent IFN response, so we specifically selected one independent IFNhi patient sample in which we had also previously measured elevated sSIGLEC-1, IL-2 and sCD25 concentrations, as well an age- and sex-matched IFNlow patient and a healthy donor8,9. This evidence concerns the gene IFNA1 and systemic lupus erythematosus.