B3GAT1 and type 1 diabetes mellitus: In agreement with the CD8+ TEM/TEMRA subset identified in our study, the CD57+ CD8+ T cells described in recently diagnosed T1D patients display a classical cytotoxic profile marked by the expression of GZMB and CD16, and were shown to be enriched for autoreactive TCR clones, suggesting a pathogenic function in autoimmunity23.