CD4 and systemic lupus erythematosus: In addition to this alteration in the CD4+ T cell compartment, we also observed a notable shift in the relative composition of the CD8+ T cell population within the IFNhi SLE patient, with a strong reduction in the proportion of naïve CD45RA+ CD8+ T cells (cluster 5) and a concomitant increase in the proportion of terminally differentiated CD8+ TEM/TEMRA (cluster 11) cells (Figure 5E).