Scramblase proteins, particularly TMEM41B and VMP1, have recently been shown to be critical in mediating lipoprotein secretion from intestine of zebrafish, cultured hepatoma cells and mouse livers, with loss of these proteins being associated with massive hepatic steatosis and near complete depletion of serum lipid levels in mouse models 14, 15. The gene discussed is VMP1; the disease is hepatocellular carcinoma.