TMEM41B and obesity due to melanocortin 4 receptor deficiency: Measurement of TMEM41B in mice with diet or genetically induced obesity revealed that TMEM41B levels were decreased compared to standard condition controls, indicating decreased TMEM41B may be a general mechanism for the development of NAFLD, upregulating de novo lipogenesis while also downregulating lipid secretion, and may serve as a potential therapeutic target for NAFLD.